Program Information

Keynote1 (July 1, 16:20-16:50)

Chair: Michiyasu Suzuki
Speaker: Jun Sakurai

Center for Innovative Clinical Medicine

Title: Investigator-initiated Clinical Trial for Medical Devices and Regulatory Points to Consider

Jun Sakurai, MD, PhD, is a radiologist and now working as Associate Professor in the Center for Innovative Clinical Medicine in Okayama University Hospital from 2015. He worked as a medical device reviewer in Pharmaceuticals and Medical Devices Agency (PMDA) from 2013 to 2015, and reviewed the applications for the new medical device approval especially for the implanted intravascular devices. Then, he promotes several investigator-initiated clinical trials and supports the collaboration between industries and academic researchers to create new medical devices and facilitate open innovation and regulatory application.

Keynote2 (July 2, 14:00-14:40)

Chair: Michiyasu Suzuki
Speaker: Akio Ikeda

Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Japan

Title: Active ictal DC shifts and red slow in epilepsy patients: other slows among pathological DC brain potentials

Akio Ikeda, MD,PhD,FACNS, is the president of Japan Epilepsy Society (JES), the Chair of Commission on Asian and Oceanian Affairs (2017-2021) of the ILAE, and the exco-members of Japanese Society of Clinical Neurophysiology (JSCN).
Besides his teaching and clinical roles, he is involved with numerous professional bodies: he is the incumbent Council Member and Chair of the Advanced EEG Seminar of the Japanese Societγ of Clinical Neurophysiology, and holds various Council and Committee Member positions in the Japanese Neurological Society.
Professor Ikeda has been working on the clinical epilepsy, wide-band EEG (ictal DC shifts) and the role of glia in epileptogenicity, and earned his PhD from Kyoto University in 1993, with his thesis on movement-related potentials recorded from the supplementary and primary motor areas of the brain (Brain,1992). He has published extensively in the literature having authored 300 original articles in English, 290 review articles, 160 book chapters and 7 books in both English and Japanese. He was an Associate Editor of Epilepsia, and Neurology & Clinical Neuroscience, and currently sits on the editorial boards of many journals.

Keynote3 (July 3, 11:10-11:50)

Chair: Michiyasu Suzuki
Speaker: Shinji Nishimoto

CiNet, National Institute of Information and Communications Technology, Japan

Title: Brain decoding and potential applications

Shinji Nishimoto received his Ph.D. in Neurophysiology from Osaka University in 2005. He worked as a Postdoctoral Fellow and an Associate Specialist at Helen Wills Neuroscience Institute at the University of California, Berkeley, from 2005 to 2013. Then, he joined the Center for Information and Neural Networks (CiNet) at the National Institute of Information and Communications Technology (NICT) as a Senior Researcher. He has also been affiliated as a Guest Professor with Osaka University Graduate School of Medicine and Frontier Biosciences. His primary research interest is the quantitative understanding of neural information processing and representations.

Keynote4 (July 3, 13:00-13:50)

Chair: Jens Dreier
Speaker: Edith Hamel

Montreal Neurological Institute, McGill University, Canada

Title: Neurovascular coupling in health and diseases

Edith Hamel is director of the Laboratory of Cerebrovascular Research at the Montreal Neurological Institute at McGill University. She obtained her PhD degree from l’Université de Montréal, and performed post-doctoral training in cerebrovascular pharmacology and physiology (USA and France), and in electron microscopy (Canada). She was President of the International Society of Cerebral Blood Flow and Metabolism (2013-2015). She received several awards including her nomination as a Fellow of the Royal Society of Canada (2017). Her research focuses on the interactions between neurons, astrocytes and blood vessels that assure a proper blood supply to activated brain areas, a phenomenon referred to “neurovascular coupling”, in both normal and disease conditions like Alzheimer’s disease and vascular cognitive impairment and dementia. She has published 156 original articles.

Session1 (SD in Migraine, July 1, 14:10-15:50)

Chair: Cenk Ayata, Fumiaki Oka

  1. Kazutaka Sugimoto
    Departments of Radiology, Massachusetts General Hospital, Harvard Medical School
    Title: Intravascular administration of endothelin-1 does not trigger or increase susceptibility to spreading depolarizations
  2. Isra Tamim
    Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School,Charlestown, Massachusetts
    Title: Cortical spreading depression and seizures: bidirectional interactions and relevance for migraine
  3. Chunhua Tang
    Department of Neurology, Keio University School of Medicine
    Title: Responsiveness to potassium-induced cortical spreading depression and subsequent c-Fos expression in a mouse model of familial
  4. Miyuki Unekawa
    Department of Neurology, Keio University School of Medicine, Tokyo
    Title: Enhanced susceptibility and wide distribution of c-Fos expression to cortical spreading depression in two-types of Na+,K+-ATPase a2 subunit-deficient mice as a model of familial hemiplegic migraine 2
  5. Minyan Wang
    Centre for Neuroscience, Department of Biological Sciences, Xi’an Jiaotong-Liverpool University
    Title: TRPA1/CGRP signaling mediates cortical spreading depression

Session2 (Mechanisms of SD, July 2,9:00-10:40)

Chair: Bill Shuttleworth, David Andrew

  1. Ning Zhou
    Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
    Title: NMDA receptors are activated in the sustained but not the initial depolarization phase during spreading depolarization
  2. Eszter Farkas
    Group of Cerebral Blood Flow and Metabolism
    Title: ?Non-spreading anoxic/ischemic depolarization
  3. Akos Menyhart
    Department of Medical Physics and Informatics,Faculty of Medicine and Faculty of Science and Informatics, University of Szeged; Szeged, Hungary
    Title: Non-spreading anoxic/ischemic depolarization is linked to impaired astrocyte function
  4. Soren Grubb
    University of Copenhagen, Copenhagen, Denmark
    Title: Precapillary sphincters exist in the brain and are involved in cortical spreading depolarization
  5. Maryam Anzabi
    Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

Session3 (SD in Injured Brain, July 2,11:10-12:50)

Chair: Eszter Farkas, Laura Ngwenya

  1. Satoshi Murai
    Department of Neurological Surgery, Okayama University Graduate School
    Title: The impact of cortical depolarization on early brain injury after subarachnoid hemorrhage in rats
  2. David Y Chung
    Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown
    Title: Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice
  3. Russell A. Morton
    Department of Neurosciences, Center for Brain Recovery and Repair University of New Mexico HSC, Albuquerque,
    Title: Spreading Depolarizations and Mild Traumatic Brain Injuries: Behavior, Cognition, and Attention
  4. Shunichi Sato
    Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute
    Title: Shock wave-induced spreading depolarization and concomitant hemodynamic abnormalities in the rat brain
  5. Takuma Nishimoto
    Department of Neurosurgery, Yamaguchi University Graduate School of Medicine
    Title: ?Effects of Intracranial Hypertension on the Cortical Spreading Depolarization

Session4 (Clinical Monitoring of SD, July 2,14:40-16:10)

Chair: Michiyasu Suzuki, Johannes Woitzik

  1. Nils Hecht
    Department of Neurosurgery, Charite ? Universitatsmedizin Berlin, Berlin, Germany
    Title: Perfusion-dependent impairment of cerebral autoregulation in malignant hemispheric stroke
  2. Tomas Watanabe
    Vagalume LLC, Palo Alto, California
    Title: Does the shape of a spreading depolarization matter?
  3. Takahito Tsukamoto
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto
    Title: Scalp EEG could record cortical spreading depolarizations (CSDs) even with time constant 2 seconds: A case report of acute traumatic brain injury and hemorrhage
  4. Stephen C. Jones
    CerebroScope, Pittsburgh
    Title:? Non-invasive detection of spreading depolarization: Initial results
  5. Sharon L Jewell
    Department of Basic and Clinical Neuroscience, King’s College London
    Title: ?A reliable method for non-invasive detection of Spreading Depolarisations using Electroencephalography
  6. Michael Ayad
    New York Presbyterian Hospital, Brooklyn
    Title: Feasibility of a wireless, endovascular stent-electrode in the superior sagittal sinus for monitoring SD

Session5 (Treatments of SD, July 2,16:40-18:40)

Chair: Andrew Carlson, Sharon Jewell

  1. Edgar Santos
    Department of Neurosurgery, University Hospital Heidelberg, Ruprecht-Karls-University Heidelberg,
    Title: Therapies that influence spreading depolarizations
  2. K.M. Reinhart
    Department of Neurosciences, University of New Mexico School of Medicine
    Title: Ketamine reduces excitotoxic consequences of spreading depolarization after stroke
  3. J. E. Weisend
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque,
    Title: A Single Spreading Depolarization can Induce Synaptic Strengthening and BDNF Upregulation
  4. Chunyan Li
    Department of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead
    Title: Trigeminal Nerve Stimulation To Modulate Cortical Spreading Depolarizations After Brain Injury
  5. Daniel P. Varga
    Department of Medical Physics and Informatics, University of Szeged, Szeged
    Title: he beneficial effect of FP receptor antagonism on spreading depolarization in cerebral ischemia
  6. Rasha H. Mehder
    Dept. Biomedical & Molecular Sciences, Queen`s University,Kingston
    Title: Surviving neurons in the ischemic core following focal stroke in mice

Session6 (Novel Technologies for monitoring SD, July 3,9:00-10:40)

Chair: Stephane Marinesco, Alan Urban

  1. A. URBAN
    1NeuroElectronics Research Flanders, IMEC, VIB, KU Leuven, Leuven, Belgium
    Title: Whole brain functional ultrasound imaging (fUSi) for detection and tracking of spreading depolarization during stroke in anesthetized rats
  2. Thomas Kirchner
    Division of Computer Assisted Medical Interventions, German Cancer Research Center
    Title: Multispectral photoacoustic imaging of hemodynamics during spreading depolarization
  3. Satoko Kawauchi
    Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute, Tokorozawa
    Title: Near-infrared reflectance imaging for monitoring spreading depolarizations and accompanying lesion progression in a rat focal cerebral ischemia model
  4. Baptiste Balanca
    Lyon neuroscience research center
    Title: Real time nitric oxide changes during spreading depolarization, ischemia and reperfusion.
  5. Stephane Marinesco
    Lyon Neuroscience Research Center, Team TIGER Faculty of medicine
    Title: Monitoring Rat Cortical Spreading Depolarizations Using Minimally-invasive microelectrode biosensors Based on Platinized Carbon Fibers

Session7 (Clinical Research on SD, July 3,13:50-15:50)

Chair: Jed Hartings, Baptiste Balanca

  1. Laura B. Ngwenya
    Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio
    Title: Spreading Depolarizations Are Associated with Worsening Pathologic Anatomy in Computed Tomographic Imaging after Severe Brain Trauma
  2. L. Schumm
    Department of Neurosurgery, Charite Universitatsmedizin Berlin
    Title: The Impact of Physiological Variables on Spreading Depolarization and Neurovascular Coupling after Malignant Hemispheric Stroke
  3. Andrew P Carlson
    Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque
    Title: Preliminary evidence that clinical manipulations are associated with increased cortical spreading depolarization in patients with acute neurologic injury
  4. Andrew P Carlson
    Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, NM
    Title: Effect of locally delivered nimodipine microparticles on spreading depolarization after aneurysmal subarachnoid hemorrhage.
  5. Shunsuke Kajikawa
    Department of Neurology, Kyoto University graduate school
    Title: Characteristics of ictal DC shifts, another infraslow EEG, recorded by scalp EEG in epilepsy patients: Comparison between scalp- and subdural recording
  6. Jens P.Dreier
    Center for Stroke Research Berlin
    Title: Correlates of spreading depolarization, spreading depression and negative ultraslow potential in human epidural versus subdural electrocorticography